MPR-RELATED ABC TRANSPORTER ENCODING NUCLEIC ACIDS AND METHODS OF USE THEREOF

摘要

Novel human MOAT genes and their encoded proteins are provided herein. The MRP-related ABC transporters encoded by the disclosed nucleic acid sequences play a pivotal role in the efflux of pharmacologically benefical reagents from tumor cells. MOAT genes and their encoded proteins provide valuable therapeutic targets for the design of anti-cancer agents which inhibit the aberrant growth of malignant cells.