| 摘要 |
<p>A prostaglandin E composition comprises are substantially free from C<SUB>1</SUB>-C<SUB>4</SUB> alcohols and include the prostaglandin E compound together with a (C<SUB>1</SUB>-C<SUB>4</SUB>)- alkyl (C<SUB>8</SUB>-C<SUB>22</SUB>) carboxylic ester (e.g., ethyl laurate), an N,N-di(C<SUB>1</SUB>-C<SUB>8</SUB>) alkylamino substituted, (C<SUB>4</SUB>-C<SUB>18</SUB>) alkyl (C<SUB>2</SUB>-C<SUB>18</SUB>) carboxylic ester and/or a pharmaceutically acceptable addition salt thereof, and optionally, a viscosity enhancing agent such as guar gum. The prostaglandin E composition can be combined with an aqueous alcoholic diluent to form a pharmaceutical composition for topical application to a patient, for example, to treat sexual dysfunction. The prostaglandin E compositions are stable for prolonged periods of storage at room temperature.</p> |
