| 摘要 |
The present invention relates to a system for improving a strain of filam entous fungus that is useful in producing an enzyme of interest such as a ce llulase. The invention involves generating genetic diversity in a strain of fungal cells, subjecting the population of cells to selection, and isolating the cells that overproduce the enzyme. The selection techniques involve cul turing the population of cells in purified cellulose and/or at an elevated t emperature that is adverse to production of the enzyme.
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