RNA INTERFERENCE AGENTS FOR GST-PI GENE MODULATION
摘要
This invention provides compounds, compositions and methods for modulating the expression of human GST-pi using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more of nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2'-deoxy nucleotides located in the seed region, as well as other nucleotide modifications
申请公布号
WO2016106400(A2)
申请公布日期
2016.06.30
申请号
WO2015US67553
申请日期
2015.12.28
申请人
NITTO DENKO CORPORATION;YING, WENBIN
发明人
YING, WENBIN;MINOMI, KENJIROU;HARBORTH, JENS;TAKAHASHI, HIROKAZU;TERADA, ERIKA;ZHANG, JUN;AHMADIAN, MOHAMMAD