| 摘要 |
FIELD: pharmaceutics.SUBSTANCE: present invention relates to a method of producing a pharmaceutical composition containing deferasirox. Method includes steps of producing dispersion of deferasirox with at least one excipient in water, homogenisation of deferasirox and at least one excipient to obtain a homogeneous dispersion of deferasirox and grinding said homogeneous dispersion until suspension with average particle size less than or equal to 2,000 nm is obtained. Also described is a pharmaceutical composition of deferasirox nanoparticles obtained using said method. Composition is intended for oral administration and is in form of a tablet. Disclosed composition is used in preparing a drug for treating chronic iron overload.EFFECT: method provides a stable and effective deferasirox composition with improved solubility.25 cl, 6 ex |
