Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
申请公布号
AU2008363828(B2)
申请公布日期
2016.09.08
申请号
AU20080363828
申请日期
2008.11.12
申请人
VERTEX PHARMACEUTICALS INCORPORATED
发明人
RUAH, SARA HADIDA S.;GROOTENHUIS, PETER D. J.;VAN GOOR, FREDRICK;MILLER, MARK T.;MCCARTNEY, JASON;ZHOU, JINGLAN;BEAR, BRIAN;NUMA, MEHDI MICHEL DJAMEL