| 摘要 |
<p>A protective antigen-specific CTL activator, preferably in the form of a plaster, which comprises the protective antigen and a pharmaceutically acceptable carrier, the activator being used for an external application to an epidermal Langerhans cell surface activated by mechanically or chemically disrupting a stratum corneum of the epidermis, in particular, an activator wherein said plaster comprises a support and an adhesive layer comprising the protective antigen in a releasable manner, said adhesive layer being laminated on one side of the support, a method for activating antigen-specific killer T cell in a mammal using said activator, and use of said protective antigen for the production of a protective antigen-specific T cell activator in a mammal. Inasmuch as the inventive antigen-specific CTL activator amplifies and activates CTL which specifically eradicates only the cells having a protective antigen, it is extremely useful for the prophylaxis and treatment of intractable cancer and diseases caused by viral infection.</p> |
