发明名称 Process for preparing 6-0-monoesters of castanospermine
摘要 The present invention relates to a process for preparing a compound of formula (I), wherein R is C1-C10 alkyl, phenyl or substituted phenyl, comprising treating a compound of formula (II), with bis(tributyltin) oxide in an organic solvent selected from the group consisting of o-xylene, m-xylene, p-xylene and mixed xylenes; and subsequently treating the reaction mixture with a compound of formula (III), wherein X is halogen and R is defined as above.
申请公布号 ZA9804180(B) 申请公布日期 1998.11.23
申请号 ZA19980004180 申请日期 1998.05.18
申请人 HOECHST MARION ROUSSEL, INC. 发明人 CHRISTIAN T. GORALSKI;SANDRA STOLZ-DUNN;JAMES E. HITT;DAVID H. LOUKS;BRIAN D. SCHERZER;DAVID H. LOUKS;MARK A. NITZ;MARK R. SMIT
分类号 A61K31/437;A61P3/10;A61P31/14;A61P35/04;C07D471/04 主分类号 A61K31/437
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