PRION PROPAGATION INHIBITION BY DOMINANT-NEGATIVE PRION PROTEIN MUTANTS

摘要

The present invention relates to a vector which is suitable for gene prophylaxis/gene therapy, containing a nucleic acid fragment coding for a mutated prion protein. The invention further relates to a vaccination agent which contains the vector in addition to the usual auxiliary agents, and to the use of the vector or vaccination agent in the prophylaxis and/or treatment of prion diseases. The invention further relates to non-human mammals, e.g. working animals, which are resistant to prion infections.