2-(substituted pyrrolidinylthio) carbapenem derivatives

摘要

A compound of the formula: (I) wherein R is a hydrogen atom or a methyl group, R1 is a hydrogen atom or a negative charge, R2 is a lower alkyl group, a lower alkyl group substituted with a hydroxyl group or -COOR3 (wherein R3 is a hydrogen atom or a lower alkyl group), A is =NH, =NR4 or =N(R4)R5 (wherein each of R4 and R5 which may be the same or different, is a lower alkyl group or a lower alkyl group substituted with a hydroxyl group), p is an integer of from 0 to 3, and each of q and r which may be the same or different, is an integer of from 0 to 5, provided that q and r are not simultaneously 0 and q +r