Nucleotide phosphonate esters characterized by the presence of an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise an ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.
申请公布号
CA2239020(A1)
申请公布日期
1997.07.10
申请号
CA19962239020
申请日期
1996.12.13
申请人
GILEAD SCIENCES, INC.
发明人
LEE, WILLIAM A.;ARIMILLI, MURTY N.;JONES, ROBERT J.;PRISBE, ERNEST J.;BISCHOFBERGER, NORBERT W.