Verfahren zur Herstellung von optisch aktiven Aminen

摘要

A novel process makes it possible to produce optically active amines of the formula (I*) in which R and R<1> have the meanings given in the description, by reacting a) in a first step, racemic amines of the formula (I) with esters of the formula (II), in which R<3> and R<4> have the meanings given in the description, in the presence of hydrolases and possibly a diluent, b) in a second step, the mixture obtained is separated into (S) amine of the formula (I-S) and acylated (R) amine of the formula (III) and c) optionally in a third step (R) amine of the formula (I-R) is released from acylated (R) amine of the formula (III) by treatment with an acid or base, possibly in the presence of a diluent. Acylated (R) amines of the formula (IIIa) in which R<11>, R<12>, R<13>, X and p have the meanings given in the description.