发明名称 |
Proces til fjernelse af desmethyl citalopram fra et citalopram produkt |
摘要 |
The present invention relates to a process for removing desmethylcitalopram having the formula <IMAGE> from a crude product containing citalopram having the formula <IMAGE> which process comprises subjecting the crude citalopram product containing the desmethylcitalopram impurity to a preliminary purification, where appropriate, and subsequently treating the crude product with an agent which forms an amide or an amide-like group, after which the reaction mixture is subjected to an acid/base wash and/or crystallization and recrystallization of the citalopram for the purpose of removing the amides which have been formed in the crude citalopram mixture; and the resulting citalopram product is purified further, where appropriate, and worked-up and isolated as the base or a pharmaceutically acceptable salt thereof.
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申请公布号 |
DK200100402(A) |
申请公布日期 |
2002.04.22 |
申请号 |
DK20010000402 |
申请日期 |
2001.03.08 |
申请人 |
H. LUNDBECK A/S |
发明人 |
VILLA, MARCO;SBROGIO, FEDERICO;DANCER, ROBERT |
分类号 |
A61P25/24;C07D307/87;(IPC1-7):C07D307/87 |
主分类号 |
A61P25/24 |
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