摘要 |
A method of calibrating an analyte sensor in vivo, which involves providing a supply of the analyte to the subject in the vicinity of the sensor, preferably as a soluble coating on the sensor, so as to saturate the sensor and obtain a maximum signal (46chem), causing the analyte in the vicinity of the sensor to be consumed so as to obtain a base line signal (46chem), and calculating a calibration function to translate the measured saturation and base line signals (46chem, 46chem) to corresponding points (45chem, 45chem) on a laboratory calibrated reference curve (45). This calibration function is subsequently used to translate any measured point (46chem) on the actual in vivo performance curve (46) of the sensor to the corresponding point (45chem) on the laboratory calibrated reference curve (45), to thereby obtain a calibrated output for the sensor in vivo taking account of the conditions found in use. <Fig. 6> |