The present application relates to methods for the enzymatic functionalization of immunoglobulins, in particular with pyrrolobenzodiazepme dimers. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
申请公布号
WO2016102632(A1)
申请公布日期
2016.06.30
申请号
WO2015EP81094
申请日期
2015.12.22
申请人
INNATE PHARMA;PAUL SCHERRER INSTITUT
发明人
BREGEON, DELPHINE;DENNLER, PATRICK;BELMANT, CHRISTIAN;GAUTHIER, LAURENT;ROMAGNE, FRANÇOIS;FISCHER, ELIANE;SCHIBLI, ROGER