Injectable, Biodegradable Bone Cements and Methods of Making and Using Same

摘要

Compositions of, methods of making, and methods of using alkaline earth phosphate bone cements are disclosed.

主权项

1. A method of delivering a drug to a subject in need thereof, the method comprising:
preparing a bone cement composition from a powder component comprising a basic source of calcium, magnesium, or strontium, and a setting solution comprising H3PO4, wherein the bone cement composition is a paste that sets into a hardened mass; dissolving a drug in the bone cement composition before the paste sets; placing or injecting the paste onto or into an anatomical location of a subject in need of the drug; and allowing the bone cement paste to set into a hardened mass to deliver the drug to the subject in need thereof.