| 摘要 |
This invention relates to new chemical compounds possessing valuable pharmaceutical activity. It particularly relates to compounds possessing antihypertensive and angiotensin converting enzyme inhibitory activity and having the structure: …<CHEM>… wherein:… Q is oxygen, sulfur or NH;… X and Y are hydrogen, halogen, hydroxy, alkoxy, trifluoromethyl, nitro, carboxy, cyano, sulfonamido, sulfhydryl, alkyl, alkenyl, alkynyl, alkanoyl, alkylmercapto, amino, alkylamino, dialkylamino, alkylsulfinyl, and alkylsulfonyl and may be the same or different;… R1 is hydrogen, alkanoyl, substituted alkanoyl wherein the substituent is hydroxy, amino or cycloalkyl, aroyl, arylakanoyl, or cycloalkylcarbonyl,… n is an integer from to 4 inclusive,… R2 and R3 are hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, aryl, aralkyl, and substituted derivatives thereof wherein the substituents are hydroxy, amino, alkylamino, dialkylamino, alkoxy, halogen, hydroxy, mercapto, alkylmercapto and nitro, and may be the same or different;… M is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, aryl, aralkyl, and hetero; and… Z is hydroxy, amino, alkylamino, dialkylamino, or alkoxy; and non-toxic pharmaceutically-acceptable salts of the said compounds. |
