| 摘要 |
The O-alkylated oximes correspond to the general formula I in which R<1> denotes a) a mononuclear or dinuclear aryl radical having up to 10 carbon atoms which may be substituted up to three times with alkyl, haloalkyl, alkoxy or dialkylamino having in each case up to 4 carbon atoms in the alkyl moiety or with halogen, phenyl, carboxyl, cyano, nitro or hydroxyl, in each case alone or in combination, or b) a 5- or 6-membered heteroaromatic radical which may be fused with a benzene ring and optionally contains a nitrogen, oxygen or sulphur atom, R2 denotes hydrogen, an alkyl group having up to 3 carbon atoms, a cycloalkyl radical which is optionally bridged over by hydrocarbon radicals and has up to 6 carbon atoms in the ring and up to 2 carbon atoms in the bridge, or a phenyl radical, R3 denotes hydrogen or a hydroxyl group which may be acylated, R4 and R5 are identical or different and denote in each case hydrogen, alkyl, haloalkyl having in each case up to 3 carbon atoms, halogen or a nitro group, and X denotes nitrogen or a methine group, and possess pharmacological, especially hypolipidaemic properties and act to reduce levels of uric acid and blood sugar. <IMAGE>
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