The present invention provides a method of producing an insulin C-peptide, which comprises expressing in a host cell a multimeric polypeptide comprising multiple copies of a said insulin C-peptide, and cleaving said expressed polypeptide to release single copies of the insulin C-peptide. Also provided are nucleic acid molecules, expression vectors and host cells, for use in such a method and the multimeric insulin C-peptide polypeptide expressed and cleaved in such a method.
申请公布号
WO9907735(A2)
申请公布日期
1999.02.18
申请号
WO1998GB02382
申请日期
1998.08.07
申请人
CREATIVE PEPTIDES SWEDEN AB;DZIEGLEWSKA, HANNA, EVA;STAAHL, STEFAN;UHLEN, MATHIAS;NYGREN, PER-AAKE;JONASSON, PER
发明人
STAAHL, STEFAN;UHLEN, MATHIAS;NYGREN, PER-AAKE;JONASSON, PER