COMPOSITIONS AND METHODS FOR ANTISENSE INHIBITION OF PROTEIN TRANSLATION
摘要
Compositions and methods are provided for inhibiting the translation of a capped target mRNA. Antisense oligomers of the invention are targeted to the 5' cap region of the target mRNA and include oligonucleosides, PNAs, or oligonucleotides modified at the 2' position of the sugar. Preferably, said oligomers inhibit protein translation directly via interference with ribosome assembly.
申请公布号
WO9745437(A1)
申请公布日期
1997.12.04
申请号
WO1997US07132
申请日期
1997.04.29
申请人
ISIS PHARMACEUTICALS, INC.;BAKER, BRENDA;BENNETT, C., FRANK;ANDERSON, KEVIN, P.;CONDON, THOMAS, P.
发明人
BAKER, BRENDA;BENNETT, C., FRANK;ANDERSON, KEVIN, P.;CONDON, THOMAS, P.