Fungicidal mono-, bi-, and tri-cycloheteroalkyl amides and their compositions, methods of use and preparation

摘要

The present invention relates to compounds of Formula I: wherein: a) represents a 6-membered heterocyclic aromatic ring in which X₁ is N and X₂, X₃ and X₄ are each independently CR''; R'' is independently H, halogen, cyano, hydroxy, C₁-C₃ alkyl, C₁-C₃ haloalkyl, cyclopropyl, C₁-C₃ alkoxy, C₁-C₃ haloalkoxy, C₁-C₃ alkylthio, aryl, C₁-C₃ NHC(O)alkyl, NHC(O)H, C₁-C₃ haloalkylthio, C₂-C₄ alkenyl, C₂-C₄ haloalkenyl, C₂-C₄ alkynyl, C₂-C₄ haloalkynyl or nitro wherein adjacent R'' substituents may form a ring; b) Z is O, S or NOR_Z in which R_Z is H or C₁-C₃ alkyl; and c) A represents (i) C₃-C₁₄ cycloalkyl, containing 1 or 3 heteroatoms and 0-2 unsaturations, which may be unsubstituted or substituted with halogen, hydroxy, C₁-C₆ alkyl, C₁-C₆ haloalkyl, cyano, nitro, aroyl, aryloxy, heteroaryloxy, C₁-C₆ alkylthio, arylthio, heteroarylthio, C₁-C₆ alkoxy, C₁-C₆ haloalkoxy, C₁-C₈ acyloxy, aryl, heteroaryl, C₁-C₆ acyl, C₁-C₆ carboalkoxy or amido unsubstituted or substituted with one or two C₁ -C₆ alkyl groups, or (ii) C₆-C₁₄ bi- or tricyclic ring system, containing 1-3 heteroatoms and 0-2 unsaturations, which may be unsubstituted or substituted with halogen, hydroxy, C₁-C₆ alkyl, C₁-C₆ haloalkyl, cyano, nitro, aroyl, aryloxy, heteroaryloxy, C₁-C₆ alkylthio, arylthio, heteroarylthio, C₁-C₆ alkoxy, C₁-C₆ haloalkoxy, C₁-C₈ acyloxy, aryl, heteroaryl, C₁-C₆ acyl, C₁-C₆ carboalkoxy or amido unsubstituted or substituted with one or two C₁-C₆ alkyl groups; which are useful as antifungal agents, particularly for plants.