| 发明名称 |
Genetically modified tumor-targeted bacteria with reduced virulence |
| 摘要 |
The present invention is directed to mutant Salmonella sp. having a genetically modified msbB gene in which the mutant Salmonella is capable of targeting solid tumors. The present invention further relates to the therapeutic use of the mutant Salmonella for growth inhibition and/or reduction in volume of solid tumors. |
| 申请公布号 |
ZA9808289(B) |
申请公布日期 |
1999.03.22 |
| 申请号 |
ZA19980008289 |
申请日期 |
1998.09.10 |
| 申请人 |
VION PHARMACEUTICALS, INC.;YALE UNIVERSITY. |
发明人 |
DAVID BERMUDES;KENNETH B. LOW;MARTINA ITTENSOHN |
| 分类号 |
A61K35/74;A61K38/00;A61K39/00;A61K39/02;A61K39/112;A61K48/00;C07K14/255;C12N1/21 |
主分类号 |
A61K35/74 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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