Complexes comprising angiostatin and its fragments, preparation preparing methods and uses thereof

摘要

In particular, the present invention discloses a conjugate of polyethylene glycol and angiostatin fragment K1-3, wherein the conjugate exhibits prolonged in vivo half-life and enhanced biological activity as compared to unmodified angiostatin fragment K1-3, and wherein the conjugate is formed by coupling one angiostatin fragment K1-3 with one polyethylene glycol molecule at the N-terminal ±-amino group of the angiostatin fragment K1-3, and said angiostatin fragment Kl-3 is the K1-3 fragment of plasminogen, or its biologically active fragment, derivative, isomer or the combination thereof.