| 摘要 |
Intermediate unsatd. piperidyl steroids. Cpds. are of formula (I): (where X-Y = or - C = CH -; A = C=O, its functional derivs., R is H or an aliphatic, araliphatic, or aromatic monocarboxylic acid; when A is C=O or its functional derivs. and X-Y satd., a double bond is opt. present at posn. 4-, 5-) are intermediates for pharmaceutical steroids of the pregnane series are prepd. by hydrolysing the corresp. C16-bromocyanamides to split off acid to give DELTA 16.17-unsatd. steroids. The cyanamido group is then reduced to the amino group using free H or aluminiumhydride complexes whereby a possible C=O group is opt. protected by ketalising, which ketal is split off after reduction.
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