摘要 |
<p>Anti depressant compositions which increase the 5-hydroxytryptophane concentration. M3A. Comprise tryptophane in its laevorotatory form and one or more of pyridoxal phosphate, of ascorbic acid and of a sugar favouring assimilation and optionally a small amount of foic acid. The compositions may be administered as a suspending tablet or as granules; the unit dose being 0.1 to 3g% laevorotatory tryptophane. Aqueous solutions may also contain one or more of glycerol, glycerol monoleate, sodium benzoate, sodium metabisulphite, a tartrazine liqueur and an aromatic agent. Capsules pref. contain aromatic agents, sodium metabisulphite and mannitol as the sugar. Other suitable sugars are dextrose, glucose and D-sorbitol. Suitable precursors of pyridoxal phosphate are pyridoxine, pyridoxal and pyridoxamine. Other adjuvants which facilitate the assimilation, hydroxylation and decarboxylation of laevorotatory tryptophane to 5-hydroxy - tryptophane may also be present.</p> |