| 摘要 |
alpha -Methyl-3,4-disubstituted phenylalanines are prepared by a process which comprises converting a 3,4-disubstituted- alpha -methylcinnamic acid derivative to a 2-methyl-2,3-dihalo-3-(3',4'-disubstituted phenyl)-propionic acid, reacting the 2,3-dihalo propionic acid with an amine to form a 3-(3',4'-disubstituted phenyl)-2-methyl-2-aziridine derivative and hydrogenolyzing the aziridine derivative to the desired product. The aziridine derivatives themselves are claimed. The alpha -methyl-3,4-disubstituted phenylalanines are useful compounds in the treatment of hypertension.
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