发明名称 |
Recombinant protein S variants deficient in C4BP binding activity, compositions and therapeutic methods |
摘要 |
The present invention describes a variant protein S protein that is substantially homologous in amino acid residue sequence to wild-type mature human protein S, which has in vitro anticoagulant activity and has a reduced ability to bind C4b binding protein (C4BP), compositions containing the variant protein S, and recombinant DNA vectors for expressing the variant protein. Also disclosed are therapeutic methods of using variant protein S for inhibiting thrombosis, inflammation and the like conditions ameliorated by protein S.
|
申请公布号 |
US5405946(A) |
申请公布日期 |
1995.04.11 |
申请号 |
US19920985691 |
申请日期 |
1992.12.02 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
GRIFFIN, JOHN H.;BOUMA, BONNO N.;BERTINA, ROGIER |
分类号 |
A61K38/00;C07K14/475;C12N15/12;(IPC1-7):C07K13/00 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|