The in vivo circulating life and/or absorption of cationic therapeutic proteins, including but not limited to basic proteins such as NT-3 and BDNF, can be increased by generating analogs that have a lower isoelectric point and, preferably, also a lower protein charge relative to the protein of native sequence.
申请公布号
WO9803546(A1)
申请公布日期
1998.01.29
申请号
WO1997US12609
申请日期
1997.07.17
申请人
AMGEN INC.;BOONE, THOMAS, C.;CHEUNG, ELLEN, NGOI, YIN;HERSHENSON, SUSAN, IRENE;YOUNG, JOHN, DAVID
发明人
BOONE, THOMAS, C.;CHEUNG, ELLEN, NGOI, YIN;HERSHENSON, SUSAN, IRENE;YOUNG, JOHN, DAVID