摘要 |
Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of formula (I) wherein: -A-A- represents the group -CHR<4>-CHR<5>- or -CR<4>=CR<5>-, R<3>, R<4> and R<5> are independently selected from the group consisting of hydrogen, halo, hydroxy, lower alkyl, lower alkoxy, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, cyano, aryloxy; R<1> represents an alpha-oriented lower alkoxycarbonyl or hydroxyalkyl radical; -B-B- represents the group -CHR<6>-CHR<7>- or an alpha- or beta-oriented group (III), where R<6> and R<7> are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano and aryloxy; and R<8> and R<9> are independently selected from the group consisting of hydrogen, hydroxy, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano and aryloxy, or R<8> and R<9> together comprise a carbocyclic or heterocyclic ring structure, or R<8> or R<9> together with R<6> or R<7> comprise a carbocyclic or heterocyclic ring structure fused to the pentacyclic D ring. |
申请人 |
G.D. SEARLE & CO.;NG, JOHN, S.;LIU, CHIN;ANDERSON, DENNIS, K.;LAWSON, JON, P.;WIECZOREK, JOSEPH;KUNDA, SASTRY, A.;LETENDRE, LEO, J.;POZZO, MARK, J.;SING, YUEN-LUNG, L.;WANG, PING, T.;YONAN, EDWARD, E.;WEIER, RICHARD, M.;KOWAR, THOMAS, R.;BAEZ, JULIO, A.;ERB, BERNHARD |
发明人 |
NG, JOHN, S.;LIU, CHIN;ANDERSON, DENNIS, K.;LAWSON, JON, P.;WIECZOREK, JOSEPH;KUNDA, SASTRY, A.;LETENDRE, LEO, J.;POZZO, MARK, J.;SING, YUEN-LUNG, L.;WANG, PING, T.;YONAN, EDWARD, E.;WEIER, RICHARD, M.;KOWAR, THOMAS, R.;BAEZ, JULIO, A.;ERB, BERNHARD |