发明名称 |
FORMULATIONS OF NONOPIOID AND CONFINED OPIOID ANALGESICS |
摘要 |
The preferred exemplary embodiments in the present application provide formulations and methods for the delivery of drugs, particularly drugs of abuse, having an abuse-relevant drug substantially confined in the core and a non-abuse relevant drug in a non-core region. These formulations have reduced potential for abuse. In the formulation, preferably the abuse relevant drug is an opioid and the non-abuse relevant drug is acetaminophen or ibuprofen. More preferably, the opioid is hydrocodone, and the non-abuse relevant analgesic is acetaminophen. In certain preferred embodiments, the dosage forms are characterized by resistance to solvent extraction; tampering, crushing or grinding. Certain embodiments of the inventions provide dosage forms that provide an initial burst of release of drug followed by a prolonged period of controllable drug release.
|
申请公布号 |
CA2690829(A1) |
申请公布日期 |
2009.01.29 |
申请号 |
CA20072690829 |
申请日期 |
2007.07.20 |
申请人 |
ABBOTT GMBH & CO. KG |
发明人 |
ROSENBERG, JOERG;WOEHRLE, GERD;KESSLER, THOMAS Y.;BREITENBACH, JOERG;DURAK, SALIH;RICHTER, FRIEDRICH W.;DUTTA, SANDEEP;LIU, WEI |
分类号 |
A61K9/28;A61K31/00 |
主分类号 |
A61K9/28 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|