TRKB AGONISTS AS NOVEL TREATMENT FOR ACUTE AND CHRONIC CARDIAC DISEASE

摘要

The present inventors have found that that BDNF/TrkB signaling acts constitutively to sustain in vivo myocardial performance. Thus, the present invention provides methods for improving cardiac contractility and methods for treating heart failure in a subject comprising administering to the subject, an effective amount of one or more TrkB agonists. Pharmaceutical compositions comprising one or more TrkB agonists and at least one additional biologically active agent and their uses are also provided.