METHODS AND COMPOSITIONS FOR TREATMENT OF RESTENOSIS

摘要

The present invention provides sequences capable of inhibiting osteopontin (OPN) expression. In particular, the sequences provided herein are antisense osteopontin oligonucleotide sequences. The present invention further provides methods for treating restenosis using antisense osteopontin oligonucleotide sequences. In particular, methods for treating restenosis following vascular surgery (e.g., percutaneous transluminal coronary angioplasty (PCTA) and directional coronary atherectomy (DCA)) by using antisense osteopontin oligonucleotide sequences are provided.