Process for the determination of APP secretase modulators and the use thereof as agents in the treatment of a Alzheimer's disease.

摘要

Described are a process for determining the activity of APP secretase using cellular model systems, those cellular systems being used directly for screening for pharmacological modulators of amyloid beta A4 release, and the modulators that can be identified and isolated by that process as pharmaceutical agents for the treatment of Alzheimer's disease. Also described are expression vectors, cells transfected with the expression vectors and the use thereof in the identification of APP secretase modulators, and a kit for determining APP secretase activity.