发明名称 |
Method for targeting degradation of intracellular proteins |
摘要 |
A method for selective targeted degradation of intracellular proteins in situ by inducing in cells a production of an agent comprising N-terminal domain as well as a C-terminal domain. The N-terminal domain destabilizes the target protein and directs its degradation when attached to it through the C-terminal domain acting as a linker between the target protein and between the protein agent of the invention. The protein degradation directing N-terminal domain is a subregion within 97 amino acids corresponding to the N-terminus of protein antizyme.
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申请公布号 |
US5866121(A) |
申请公布日期 |
1999.02.02 |
申请号 |
US19960603575 |
申请日期 |
1996.02.23 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
COFFINO, PHILIP;LI, XIANQIANG |
分类号 |
A61K38/00;C07K14/435;C07K14/47;C12N9/88;C12N15/62;(IPC1-7):A61K38/48;A61K38/51;G01N33/53;C12P21/06 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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