发明名称 |
METHODS FOR THE IDENTIFICATION, EVALUATION AND TREATMENT OF PATIENTS HAVING CC-CHEMOKINE RECEPTOR 2(CCR-2) MEDIATED DISORDERS |
摘要 |
The present invention is directed to the identification of predictive genotypes, e g, predictive single nucleotide polymorphisms (SNPs), and markers that can be used to determine whether a patient having a CC-Chemokine Receptor 2 (CCR-2) mediated disorders is likely to be responsive or non-responsive to a therapeutic regimen. For example, the present invention is directed, in part, to the use of certain individual and/or combinations of SNPs, wherein the expression of particular alleles at particular SNPs, or combinations of alleles at loci in linkage disequilibrium with a particular SNP, correlate with responsiveness or non-responsiveness to a therapeutic regimen. The present invention is also directed to the use of certain individual and/or combinations of predictive markers which correlate with responsiveness or non-responsiveness to a therapeutic regimen. Thus, by examining allelic expression at particular SNPs, combinations of alleles at loci in linkage disequilibrium with a particular SNP, or expression levels of individual predictive markers and/or predictive markers comprising a marker set, it is possible to determine whether a patient having a CCR-2 mediated disorder will likely respond or not respond to a therapeutic regimen. |
申请公布号 |
WO2008033461(A2) |
申请公布日期 |
2008.03.20 |
申请号 |
WO2007US19926 |
申请日期 |
2007.09.13 |
申请人 |
MILLENNIUM PHARMACEUTICALS, INC.;PARKER, ALEXANDER, N.;DONALDSON, DEBRA, D. |
发明人 |
PARKER, ALEXANDER, N.;DONALDSON, DEBRA, D. |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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地址 |
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