| 摘要 |
<P>PROBLEM TO BE SOLVED: To establish human pluripotent stem cells having resembling properties with human ES cells consisting of the genome of patient himself and capable of avoiding the immunological rejection of transplanted cells, from cells originated from human tissue after birth. <P>SOLUTION: It is found out that the human pluripotent stem cells can be induced by introducing three genes of Oct3/4, Sox2 and Klf4, or three genes of the Oct3/4, Sox2 and Klf4, and c-Myc gene or a histone deacetylase (HDAC) inhibitor to the undifferentiated stem cells in which each of genes of Tert, Nanog, Oct3/4 and Sox2 existing in various human tissues after the birth has not received epigenetic inactivation. <P>COPYRIGHT: (C)2009,JPO&INPIT |
