发明名称 |
METHODS OF TREATING BRAIN ISCHEMIA OR HYPOXIA |
摘要 |
Provided are methods of treating brain ischemia or hypoxia by using an inhibitor of cysteine-glutamate transporter. The inhibitor includes sorafenib and a derivative thereof, regorafenib, erastin and sulfasalazine. The inhibitor can effectively decrease a concentration of extracellular glutamate, so that excitotoxicity to nervous system and a cortical infarct volume in brains may be reduced. |
申请公布号 |
WO2016110160(A1) |
申请公布日期 |
2016.07.14 |
申请号 |
WO2015CN94827 |
申请日期 |
2016.01.07 |
申请人 |
CHINA MEDICAL UNIVERSITY |
发明人 |
HSIEH, CHIA-HUNG;LIN, YU-JUNG;SHYU, WOEI-CHERNG |
分类号 |
A61K31/635;A61K31/44;A61K31/495;A61P9/10;A61P25/00;A61P35/00 |
主分类号 |
A61K31/635 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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