| 发明名称 |
CHOLERA TOXIN A-LIKE POLYPEPTIDE USEFUL AS ADJUVANT COMPONENT |
| 摘要 |
A cholera toxin-like polypeptide useful as adjuvant is provided. Polynucleotide coding to the polypeptide and associated vectors, host cells and methods of production are provided. Adjuvants, compositions comprising the polypeptide, and uses thereof are also provided. |
| 申请公布号 |
US2016244488(A1) |
申请公布日期 |
2016.08.25 |
| 申请号 |
US201415023664 |
申请日期 |
2014.09.23 |
| 申请人 |
GOTOVAX AB |
发明人 |
Holmgren Jan;Lebens Michael |
| 分类号 |
C07K14/195;C12P21/02;A61K39/02 |
主分类号 |
C07K14/195 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A cholera toxin A subunit (CTA)-like polypeptide having at least 90% sequence identity to CTA (SEQ ID NO: 1), characterized in that:
a. the CTA-like polypeptide contains one or more mutations in its sequence rendering the trypsin cleavage site between amino-acids 192 and 193 of CTA trypsin-resistant; and b. the CTA-like polypeptide contains one or more mutations in its sequence rendering the Vibrio cholerae HAP cleavage site between amino-acids 197 and 198 of CTA HAP-resistant. |
| 地址 |
Västra Frölunda SE |
