CHROMENE DERIVATIVES SUBSTITUTED BY ALKOXIDE AS INHIBITORS OF THE TCR-NCK INTERACTION

摘要

The present invention relates to a group of compounds of formula (I) containing a chromene nucleus:;;and that present the capacity to inhibit the proliferation of lymphocytes mediated by the Nck interaction with TCR, so that the present invention also relates to the use of these compounds for the treatment of diseases or conditions where said interaction triggers a complication such as transplant rejection reactions, immune or autoimmune diseases, inflammatory diseases or proliferative diseases.

主权项

1. A compound having the structure of formula (I)or a pharmaceutically acceptable salt, isomer or solvate thereof wherein:
R1 is selected from hydrogen, substituted or not substituted C1-C6 alkyl, substituted or not substituted C3-C6 cycloalkyl, substituted or not substituted aryl or substituted or not substituted heteroaryl, —COR5, —C(O)OR5, —C(O)NR5R6, —CNR5, R2 and R3 are each independently selected from hydrogen, substituted or not substituted C1-C6 alkyl, substituted or not substituted C3-C6 cycloalkyl, substituted or not substituted aryl, substituted or not substituted heteroaryl, —COR7, —C(O)OR7, —C(O)NR7R8, —CNR7, —OR7, —NR7R8 and —NR7C(O)R8; or R2 and R3 form, together with the nitrogen atom they are bound to, a substituted or not substituted heterocycle; R4 is a halogen; R5, R6, R7 and R8 are each independently selected from hydrogen, C1-C4 alkyl, C3-C6 cycloalkyl, aryl, heteroaryl and halogen with the proviso that the compound of formula (I) is not 1-(4-(4-fluorophenyl)-6-methoxy -2H-chromene-3-yl)methyl)pyrrolidine.