| 摘要 |
The following are claimed: (A) ameliorating cellulite conditions, comprising application of a topical treatment compsn. to skin areas overlying cellulite, the treatment compsn. being effective to chronically disrupt the barrier function of the stratum corneum and to inhibit barrier repair; (B) ameliorating cellulite conditions, comprising application of a topical treatment to skin areas overlying cellulite, the treatment being effective to disrupt the water barrier function of the stratum corneum and to induce chronic elevated trans-epidermal water loss for a period of from 8 weeks until amelioration of cellulite is achieved. The treatment is selected from skin water barrier disruption treatments consisting of application of exfoliants in soln., mechanical abrasion and solvent extraction of hydrophobic skin barrier components; (C) cellulite treatment compsn. for topical application to cellulite-afflicted skin areas, the compsn. being effective to disrupt the barrier function of the stratum corneum. The compsn. comprises: (a) 1-15 wt. % (based on the wt. of the compsn.) of a pH-reducing, hydroxycarboxylic acid; (b) 0.005-6 wt. % (based on the wt. of the compsn.) of a retinoid cell renewal stimulant; and (c) 0.01-5 wt.% (based on the wt. of the compsn.) of a cerebroside barrier repair inhibitor to inhibit repair of the skin's water barrier; (D) cellulite treatment compsn. comprising an agent to disrupt the barrier function of the stratum corneum, a cell renewal stimulant and a barrier repair inhibitor to inhibit repair of the skin's water barrier. |
