发明名称 |
Methods for identifying compounds that modulate biofilm activity |
摘要 |
The invention features a novel method for identifying compounds capable of affecting a microbial biological activity, such as biofilm formation, development and dissolution. The method includes: (a) obtaining supernatant from a closed culture system that contains at least one type of microorganism; (b) exposing a target organism to the supernatant or an extract thereof; and (c) measuring the level of the biological activity. Compounds identified by this method are provided, as well as methods for disrupting biofilms and inhibiting or promoting their formation. |
申请公布号 |
AU9489501(A) |
申请公布日期 |
2002.04.08 |
申请号 |
AU20010094895 |
申请日期 |
2001.09.28 |
申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE;TRUSTEES OF DARTMOUTH COLLEGE |
发明人 |
GEORGE A. O'TOOLE;DAVID H. BLANK;MARY ELLEN DAVEY;NICKY C. CAIAZZA;ROBERTO KOLTER;DEBORAH A. HOGAN |
分类号 |
C12Q1/02;C12Q1/18 |
主分类号 |
C12Q1/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|