摘要 |
<p>We disclose GPR146 G-protein coupled receptor (GPCR) polypeptides comprising the amino acid sequence shown in SEQ ID NO. 3 or SEQ ID NO: 5, and homologues, variants and derivatives thereof. Nucleic acids capable of encoding GPR146 polypeptide are also disclosed, in particular, those comprising the nucleic acid sequences shown in SEQ ID No. 1A, SEQ ID No.1 B, SEQ ID No.2 or SEQ ID NO: 4. The GPR146 receptor is useful in the diagnosis and therapy of dyslipidaemias.</p> |
申请人 |
PARADIGM THERAPEUTICS LTD.;GROSSE, JOHANNES;POWELL, JUSTIN;DIXON, JOHN;THRESHER, ROSEMARY;DAY, KATE |
发明人 |
GROSSE, JOHANNES;POWELL, JUSTIN;DIXON, JOHN;THRESHER, ROSEMARY;DAY, KATE |