Partial derivatization of particles

摘要

There is disclosed a method for partially derivatizing a curved surface of particles in an electrically conducting solvent, said method comprises the steps: a) bringing particles in close contact with at least one surface by using a force, b) inducing a chemical reaction on at least one part of a particle by applying an electrical potential between said at least one surface and the electrically conducting solvent, and c) further reacting said at least one part of a particle where a chemical reaction has been induced in step b) above. There is further disclosed a partially derivatized particle as well as uses of the particle. Advantages include that the method is simple and only requires a potentiostat in addition to standard laboratory equipment, is inexpensive, time-efficient, and inherently parallel.

主权项

1. A partially derivatized particle prepared by a method for partially derivatizing a curved surface of particles in an electrically conducting solvent, said method comprising the steps:
a. bringing particles in close contact with at least one surface by using a force, b. inducing a chemical reaction on at least one part of a particle by applying an electrical potential between said at least one surface and the electrically conducting solvent, and c. further reacting said at least one part of a particle where a chemical reaction has been induced in step b) to covalently bind molecules thereto, wherein the sequential steps a, b, and c are repeated, with repeated steps b and c directed to another at least one part of the particle to covalently bind different molecules thereto, wherein the particle has at least two different derivatized patches, wherein the covalently bound molecules on one of the two patches differ from the covalently bound molecules on the other of the two patches, wherein the covalently bound molecules on each patch are covalently bound to the same type of chemical groups on the particle, and wherein the at least two patches form a pattern.