Polynucleotides encoding BSL2v2c2-Ig

摘要

The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

主权项

1. An isolated polynucleotide comprising a sequence selected from the group consisting of:
(a) an isolated polynucleotide comprising nucleotides encoding amino acids 1 to 480 of SEQ ID NO:135; (b) an isolated polynucleotide comprising nucleotides encoding amino acids 2 to 480 of SEQ ID NO:135; and (c) an isolated polynucleotide comprising nucleotides encoding amino acids 29 to 480 of SEQ ID NO:135.