STABLE HELICAL IONIC POLYPEPTIDES

摘要

The invention provides polymers comprising Formula I:;;wherein monomer is a repeating unit comprising 2, 3, 4, 5, 6 or 7 carbon atoms and the monomers are linked together through amide or ester bonds; n is about 6 to about 1000; and Linker is an optionally substituted carbon chain that is optionally interrupted by moieties such as oxygen, nitrogen, sulfur, phosphorus, or silicon. Charge is a moiety having a positive or negative charge on a heteroatom, such as nitrogen, oxygen, phosphorus, or sulfur; where the Linker separates the monomer and the Charge by at least six linear atoms. The invention also provides methods of preparing the polymers and the copolymers and methods of using the polymers and copolymers, for example, as drug delivery systems, as membrane penetrating peptides, and as therapeutic agents.

主权项

1. A polymer comprising Formula IA:wherein
n is about 6 to about 1000; q is 0 to about 5; r is 0 to about 5; R13 is H, absent, an aromatic group, or an aliphatic group, wherein the aromatic group or aliphatic group is optionally substituted; Linker is a chain of atoms that is 6 atoms or longer; and * is a positively or negatively charged moiety, wherein the moiety having the positive or negative charge comprises a cationic nitrogen of a nitrogen heterocycle, a guanidinium group, a hydrazone, a hydrazide, or a hydrazine, or an anionic oxygen of a carboxylate; or a salt thereof.