发明名称 |
伸長α鎖を有するフィブリノーゲンが濃縮されたフィブリノーゲン調製物 |
摘要 |
The present invention relates to fibrinogen preparations enriched in α-extended fibrinogen. Compositions comprising such preparations show improved clotting properties compared to preparations based on HMW Fib which typically contain no or only low amounts of α-extended fibrinogen. In particular, clot formation time and the clot strength of a clot made by α-extended fibrinogen are improved. In addition, plasmin-mediated degradation of α-extended fibrinogen is reduced as compared to plasma derived fibrinogen. |
申请公布号 |
JP5960606(B2) |
申请公布日期 |
2016.08.02 |
申请号 |
JP20120547516 |
申请日期 |
2011.01.07 |
申请人 |
プロフィブリックス ビーブイ |
发明人 |
グリムベルゲン,ヨセフ;コープマン,ヤコブ;バウト,アブラハム |
分类号 |
C07K14/75;A61K38/43;A61K38/48;A61P7/04;A61P17/02;A61P41/00;C12N9/74;C12N15/09 |
主分类号 |
C07K14/75 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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