| 摘要 |
Compositions for topical application to the epidermis at an afflicted situs for the treatment of anomalous mobilization and deposition of calcium phosphate salts in the tissues of humans and other animals, are disclosed. The compositions comprise: (i) from about 0.5% to about 20 of a pharmaceutically acceptable organophosphonate compound; and (ii) a carrier which comprises from about 0.1% to about 15% of the composition of an organosulfoxide compound, wherein said organosulfoxide compound is a dialkylsulfoxide of the formula R'R"SO wherein group R' is a C6-C20 alkyl or substituted alkyl group and wherein group R" is a Cl-C3 alkyl or substituted alkyl group, the balance of said carrier comprising a pharmaceutically acceptable, compatible liquid, wherein the pH of aqueous solutions of the composition is from about 3.5 to about 10. |
