| 摘要 |
Antiarrhythmic title compds. (I; R1, R3=H, OMe, R2, R4=H, F, Br, Me, OMe; OEt, iso-propoxy, methylthio, NO2, amino, acetylamino; R5, R6, R7, R8=H, Me, Et, Pr, iso-propyl, Bu, C6H5, p-OMeC6H4, phenylpropyl; A, B=ethylene, 1-methylethylene, propylene, Bu, n-hexyl, C6H5, phenylethyl, phenylpropyl were prepd. Thus, reaction of 19 g(0.1 mol) 4, 4-dimethyl-isochromandion-1, 3 with CH3N(CH2CH2CH2NH2)2 in HO(CH2)2-OH at 180≦̸C, 4hr gives 65% I(R1, R2, R3, R4=H; R5, R6, R7, R8, R9=Me; A, B=Pr). EC50 and ED50 for I were 5.5 mg/ml and mg/kg in mice, resp.
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