| 摘要 |
Compounds represented by the formula <IMAGE> wherein R1, R2 and R3 are lower alkyl, R4 is lower alkoxy, R6 and R8 are methyl or trifluoro methyl, R9 is formyl, hydroxymethyl, alkoxymethyl, alkanoyloxymethyl, carboxyl, alkoxycarbonyl, lower alkenoxycarbonyl, lower alkynoxycarbonyl, carbamoyl, mono(lower alkyl)-carbamoyl, di(lower alkyl)carbamoyl or N-heterocyclylcarbonyl, R5, R7, R10, R11, R12 and R13 are hydrogen or fluorine with the proviso that at least one of R5, R7, R10, R11, R12 or R13 is fluorine or at least one of R6 or R8 is trifluoro methyl, or pharmaceutically acceptable salts thereof useful as antitumor agents are disclosed.
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