| 摘要 |
Indane derivatives with the formula: …<CHEM>… wherein R1 is H, Halogen, an alkyl group having from one to three carbon atoms inclusive, methoxy, a methylthio-group, or a trifluoromethyl group,… n is 2-4,… X is O or S,… Y is O, CH2 or N-R2, where R2 is hydrogen or an (1-6 C) alkyl, (1-6 C) alkenyl or cycloalkyl-methyl group having from three to six carbon atoms,… Z is -(Ch2)n-, n is 2 or 3 or Z is 1,2-phenylene optionally substituted with halogen or trifluoromethyl or Z = 1,2-C6H4CO- (to form a quinazolidinone or -thione ring system).… U = N or C, … geometric isomers thereof as well as pharmaceutically acceptable acid addition salts are potent 5-HT2 antagonists useful in the treatment of cardiovascular diseases including hypertension and anxiety. …<??>Method for the preparation of said compounds are also described. |
